Daniel Kaplan, MD, PhD Associate Professor, Immunology
The skin is a barrier organ that is exposed to a wide variety of potential pathogens including bacteria, fungi and viruses. Within the skin there are numerous components of both the innate and adaptive immune system. The research focus of my lab is to understand how these skin resident immune cells (e.g. dendritic cells, T cells) interact with specific pathogens and other non-immune cells in the skin to contribute to the development of both innate and adaptive immune responses that provide host protection. Specific projects include:
- Development of innate and adaptive responses to epicutaneous C. albicans infection
- Relationship of pain sensing neurons in the skin with host defense
- Ability of keratinocytes to retain dendritic cells and T cells in the epidermis
- Development of humoral responses to cutaneous pathogens
- Plasticity of individual skin-resident dendritic cell subsets.
- Tolerance and suppression of immune responses by Langerhans cells