MSNBIO 2622 - Spring 2012

Mechanisms and Clinical Presentation of Pain Schedule through February

(MSNBIO 2622, 3 semester hours)

Mondays and Thursdays, 3:30 - 5:00 p.m., 1495 BSTWR

G.F. Gebhart, Course Director
Phone: 412-383-5911
Location: W1444 BSTWR

DateTopicPresenterReading Assignments
09 JanuaryCourse organization, pain taxonomy, overview
Pain Fellows case reports:
  • C.Yang

G. Gebhart


- Melzack & Wall (1965) - Pain mechanisms: A new theory
- E. Perl (2006) - Ideas about pain, a historical view
12 JanuaryNociceptors (definition, assessment, heterogeneity, characteristics)G. Gebhart- Snider & McMahon (1998) - Tackling pain at the source: New ideas about nociceptors
- Djouhri & Lawson (2004) -Aβ-fiber nociceptive primary afferent neurons...
16 JanuaryNo Class - Martin Luther King Holiday  
19 JanuaryPain Fellows case reports:
  • D. Kohane
  • W. Salama
  • R. McHugh
23 JanuaryPain Fellows case reports:
  • J. Becerra
  • G. Toshniwal
  • G. Yacob
26 JanuaryInjury-induced changes in afferent signalingM. Gold- Hucho & Levine (2007) - Signaling pathways in sensitization
- Gold & Gebhart (2010) - Nociceptor sensitization in pain pathogenesis
- Cregg et al. (2010) Pain channelopathies
30 JanuaryDorsal horn - structure and functionR. Koerber- Todd (2010) - Neuronal circuitry for painprocessing in the dorsal horn
02 FebruaryInjury-induce changes in dorsal horn signalingS. Prescott- Sandkuhler (2009) - Models and mechanisms of hyperalgesia
06 FebruaryAcending pathwaysD. Molliver-Craig (2003) Pain Mechanisms
-Schweinhardt and Bushnell (2010) Pain imaging in health disease
09 FebruaryDescending modulatory pathways
G. Gebhart
- Ossipov et al (2010) – Central modulation of pain
13 FebruaryItch and painS. Ross
- Ikoma et al (2006) - The neurobiology of itch
15 FebruaryRobert Edwards SeminarAllAll 4:00, Room 1105A Scaife Hall
16 FebruaryGrowth factors, cytokines, chemokines and pain
K. Albers
- Miller et al. (2009) - Cytokine and chemokine regulation of sensory neuron fuction
20 FebruarySupraspinal representation of painJ. Ibinson- Schweinhardt & Bushnell (2010) - Pain imaging in health and disease
23 FebruaryNeuropathic pain (models, mechanisms)
Distribution of Progress Exam, due back 27 Feb
S. Prescott- Costigan et al. (2009) - Neuropathic pain: A maladaptive response of the nervous system to damage
27 FebruarySex and painM. Gold- Fillingim (2010), Sex, Gender and Pain -Mogil and Bailey (2010) Sex, Gender differences in pain and analgesia
01 MarchCancer pain (models and mechanisms)B. Davis-Bapat et al (2011)Perineural invasion and associated
pain in pancreatic cancer
-Raphael et al (2010) Cancer Pain
4-11 MarchNo Classes - Spring Break  


12 MarchPain genetics (basic, non-human animal)W. Lariviere-Lariviere Gen NcPain (2009) -Lariviere Mogil Meth Mol Biol (2010) -AVPR1A Nat Neurosci (2011)
15 MarchPain genetics (human)I. Belfer-Lo¨tsch and Geisslinger (2007) Cur evid modul nocic human gen polymorphism -Young et al (2011) Gen basis pain variability: recent advances -Belfer and Segall (2011) Comt gen variants and pain
19 MarchPsychosocial assessment and behavioral treatment of chronic painC. Greco, Psychiatry-Mcbeth et al (2011)Cognitive Behavior Therapy
21 MarchRu-Rong Ji Seminar All4:00, Room 1105A Scaife Hall
22 MarchNo Class 


26 MarchNo Class 


29 MarchPain and depressionJ. Karp- Moskowitz & Fishman (2006) – The Neurobiological and therapeutic.
02 AprilOpioid management of chronic pain - use and misusesG. Wood, Medicine, Palliative Care-Von Korff et al (2011) Opioids reconsidered
05 AprilHeadacheR. Kaniecki, Director, Headache Center-Levy(2012)Endogenous Mechanisms -Mainero et al (2011)Altered Functional
09 AprilVisceral pain (clinical presentation, mechanisms)
Student papers due - 5:00pm
K. Bielefeldt, Medicine/GI

-Knowles (2009)Basic and clinical aspects of gastrointestinal pain

12 AprilTBA  
16 AprilStudent PresentaitonsAll 
19 AprilStudent PresentaitonsAll 

     If you have a disability for which you are or may be requesting an accommodation, you are encouraged to contact both the course director and Disability Resources and Services, 216 William Pitt Union, (412) 648-7890/(412) 383-7355 (TTY), as early as possible in the term.  DRS will verify your disability and determine reasonable accommodations for this course.

     1. Students registered in the course will be asked to select from a list a topic for a paper (10 double spaced pages, not including references, figures or tables).  The paper is Due Monday 5pm, 9 April and will constitute - in conjuction with the oral presentation of the topic - about 50% of the course grade.  Students will give an oral presentation (20-30 min) of the paper/topic at the end of the semester.

Schedule for Spring 2008
Schedule for Spring 2009
Schedule for Spring 2011